Information identified as archived is provided for reference, research or recordkeeping purposes. It is not subject to the Government of Canada Web Standards and has not been altered or updated since it was archived. Although quantitative data are very limited, bis 2-ethylhexyl phthalate is released into the Canadian environment as a result of its manufacture and its industrial uses. Relatively small amounts of the substance are also released from some plastic goods. This page has been archived on the Web Information identified as archived is provided for reference, research or recordkeeping purposes.
Print infocard Open Brief Profile. Trotter twins 2-ethylhexyl e Bis phthalate kyseliny ftalo ve Czech. European Priority List and Risk Assessments. Phthaalte, 74 5, Bsi Spectra nist ri From Wikipedia, the free encyclopedia. InfoCards are Bis phthalate when new information is available. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. Prenatal phthalate exposure has been shown to be associated with lower levels of reproductive function in Bis phthalate males. Virtual Library.
Tna erotic spice review forumns. Secondary content
Human Reproduction Update. Although the word "phthalate" appears in the name, PETE does not use phthalates as plasticizers. Recommendation to amend authorisation list entries - previous consultation. Welcome to the ECHA website. Phthalates are also frequently used in soft plastic fishing lures, caulkpaint pigments, and sex toys made Bis phthalate so-called "jelly rubber". They are mainly used as Bis phthalatei. Further information: Taiwan food scandal. Restriction list. Registered substances factsheets. The terephthalate polymer PETE and the phthalate ester plasticizers are chemically different substances. Laurie zink naked 2-ethylhexyl -phthalat. DEHP also finds use as a solvent in glowsticks. Infocards are automatically generated based on industry data.
Back Home Products Phthalic anhydride, plasticizers and esters.
- It is the diester of phthalic acid and the branched-chain 2-ethylhexanol.
- They are mainly used as plasticizers , i.
Back Home Products Phthalic anhydride, plasticizers and esters. Phthalic anhydride. Following the recent articles in the press about the future of bis 2-ethylhexyl phthalate DEHP; CAS: , DEZA regards it as appropriate to clarify its position for this general purpose plasticizer. It should also be highlighted that DEZA has built and is continuously strengthening its position in the field of higher molecular general purpose plasticizers, namely phthalates like di-''isononyl''phthalate DINP; CAS: and bis 2-propylheptyl phthalate DPHP CAS: , consistent with market requirements.
This enrichment is further proof of DEZA's commitment towards the strategic goal of satisfying the needs of the plasticizer users, now and in the future. Private policy Sitemap. Back Home Products Phthalic anhydride, plasticizers and esters Phthalic anhydride, plasticizers and esters Seller: Bc. Did you know that Phthalic anhydride is produced by oxidising naphthalene. Phthalic anhydride is used in the production of colouring agents, resin and phthalate softeners for PVC.
New REACH chemical legislation re-evaluates the properties of phthalates, particularly dibutyl phthalates and dioctyl phthalates DEHP and evaluates their use in selected applications.
Information on precautionary measures and the safe use is submitted by the registrant of a substance and the registrant is solely responsible for its accuracy and completeness. Higher air temperatures result in higher concentrations of phthalates in the air. Additionally , the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child and is very toxic to aquatic life. Transfusion Medicine. Even at relatively low doses of DEHP, cardiovascular reactivity was significantly affected in mice.
Bis phthalate. Navigation menu
It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three billion kilograms are produced annually worldwide.
Industrial production entails the reaction of phthalic anhydride with 2-ethylhexanol :. Manufacturers of flexible PVC articles can choose among several alternative plasticizers offering similar technical properties as DEHP. DEHP is a component of many household items, including tablecloths, floor tiles, shower curtains, garden hoses, rainwear, dolls, toys, shoes, medical tubing, furniture upholstery, and swimming pool liners.
Common exposures come from the use of DEHP as a fragrance carrier in cosmetics, personal care products, laundry detergents, colognes, scented candles, and air fresheners. For this reason, concern has been expressed about leachates of DEHP transported into the patient, especially for those requiring extensive infusions or those who are at the highest risk of developmental abnormalities, e. FDA issued a Public Health Notification on DEHP, stating in part, "We recommend considering such alternatives when these high-risk procedures are to be performed on male neonates, pregnant women who are carrying male fetuses, and peripubertal males" noting that the alternatives were to look for non-DEHP exposure solutions;  they mention a database of alternatives.
If a procedure requires one of these devices and if patient is at high risk to suffer from DEHP then a DEHP alternative should be considered if medically safe. The released alcohol is susceptible to oxidation to the aldehyde and carboxylic acid. Prenatal phthalate exposure has been shown to be associated with lower levels of reproductive function in adolescent males.
Numerous studies of DEHP have shown changes in sexual function and development in mice and rats. DEHP exposure during pregnancy has been shown to disrupt placental growth and development in mice, resulting in higher rates of low birthweight, premature birth, and fetal loss.
MEHP is suspected to have an obesogenic effect. Rodent studies and human studies have shown DEHP to be a possible disruptor of thyroid function, which plays a key role in energy balance and metabolism. Exposure to DEHP has been associated with lower plasma thyroxine levels and decreased uptake of iodine in thyroid follicular cells. Previous studies have shown that slight changes in thyroxine levels can have dramatic effects on resting energy expenditure, similar to that of patients with hypothyroidism , which has been shown to cause increased weight gain in those study populations.
Even at relatively low doses of DEHP, cardiovascular reactivity was significantly affected in mice. This includes an uncoupling effect that leads to irregular rhythms in vitro.
Untreated cells had fast conduction velocity, along with homogenous activation wave fronts and synchronized beating. Cells treated with DEHP exhibited fractured wave fronts with slow propagation speeds. This is observed in conjunction with a significant decrease in the amount of expression and instability of gap junctional connexin proteins, specifically connexin , in cardiomyocytes treated with DEHP. The decrease in expression and instability of connexin may be due to the down regulation of tubulin and kinesin genes, and the alteration of microtubule structure, caused by DEHP; all of which are responsible for the transport of protein products.
Also, DEHP caused down regulation of several growth factors, such as angiotensinogen , transforming growth factor-beta , vascular endothelial growth factor C and A , and endothelial The DEHP-induced down regulation of these growth factors may also contribute to the reduced expression and instability of connexin DEHP has also been shown, in vitro using cardiac muscle cells, to cause activation of PPAR-alpha gene, which is a key regulator in lipid metabolism and peroxisome proliferation; both of which can be involved in atherosclerosis and hyperlipidemia , which are precursors of cardio vascular disease.
Studies in mice have shown other adverse health effects due to DEHP exposure. Ingestion of 0. DEHP is also a possible cancer causing agent in humans, although human studies remain inconclusive, due to the exposure of multiple elements and limited research. In vitro and rodent studies indicate that DEHP is involved in many molecular events, including increased cell proliferation, decreased apoptosis , oxidative damage , and selective clonal expansion of the initiated cells; all of which take place in multiple sites of the human body.
In May , the illegal use of the plasticizer DEHP in clouding agents for use in food and beverages has been reported in Taiwan. A proposal to make the ban permanent was tabled. From Wikipedia, the free encyclopedia. CAS Number. Interactive image. PubChem CID. Chemical formula. Solubility in water. GHS hazard statements. GHS precautionary statements. LD 50 median dose. PEL Permissible. IDLH Immediate danger. Further information: Taiwan food scandal. Retrieved 17 March Retrieved Food additives and contaminants.
GreenFacts Website. Transfusion Medicine. Environmental Research. Bibcode : ER Fertility and Sterility. Journal of Hazardous Materials. Toxicological Sciences. Toxicology and Applied Pharmacology. Journal of Cancer Prevention. Reproductive Biology. Christopher European Solvents Industry Group. Archived from the original on Health issues of plastics and polyhalogenated compounds PHCs.